Boost the performance benefits from creatine with added betaine

Betaine has numerous roles within the body that support various bodily process that may deliver performance benefits, particularly when combined with creatine.

Betaine – also called betaine anhydrous – is a compound naturally present in some foods, including beets, spinach, quinoa, certain seafood and grains like wheat bran. Our body also manufactures some of the betaine we need through a conversion process involving choline.

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Better body composition

In terms of its potential performance benefits, a study1 conducted on untrained collegiate females found that a betaine supplement may improve body composition by enhancing “reductions in fat mass” when accompanied by a resistance training program.

In addition, betaine may potentially boost protein synthesis, as study2 participants in a 2013 study who took a supplement for six weeks “improved body composition”, showing improvements in body fat percentage, fat mass and lean body mass. They also increased arm size, which indicates they added muscle mass.

Some research3 links this muscle-building benefit to betaine’s effect on homocysteine, which is a substance that “directly impairs insulin signaling”.

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Performance benefits

From an athletic perspective, betaine anhydrous has been shown to aid muscle development and may provide a performance boost.

In one study4, researchers concluded that betaine anhydrous may improve muscle strength and power by increasing total work capacity during exercise. This improved fatigue resistance came after active college males supplemented with betaine for two weeks. The control group taking the supplement “appeared to improve muscle endurance of the squat exercise, and increase the quality of repetitions performed”.

And betaine may also boost the benefit you get from one of the most ergogenic substances available – creatine. A 2022 study5 determined that betaine supplementation may have ergogenic effects by increasing creatine levels, with other research supporting betaine’s role in creatine synthesis.

By acting as a methyl donor in the body, betaine supports methionine production from S-adenosylmethionine (SAM), a key player in creatine production. Some animal studies6 and human trials have shown that betaine supplementation can increase SAM levels, potentially leading to higher creatine levels.

Biogen Creatine + Betaine is a performance blend of creatine HCL and creatine monohydrate to increase power output to assist with muscle development, coupled with 1250mg of betaine per serving to support muscle development and provide a proven performance boost.

Added betaine supports muscle growth and strength output with coconut water powder to support optimal hydration and Beta-alanine for an added endurance boost.


  1. Cholewa JM, Hudson A, Cicholski T, Cervenka A, Barreno K, Broom K, Barch M, Craig SAS. The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial. J Int Soc Sports Nutr. 2018 Jul 31;15(1):37. doi: 10.1186/s12970-018-0243-x. PMID: 30064450; PMCID: PMC6069865.
  2. Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, Jakubowski H, Matthews T, Wood R, Craig SA, Paolone V. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013 Aug 22;10(1):39. doi: 10.1186/1550-2783-10-39. PMID: 23967897; PMCID: PMC3844502.
  3. Li Y, Jiang C, Xu G, Wang N, Zhu Y, Tang C, Wang X. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes. 2008 Apr;57(4):817-27. doi: 10.2337/db07-0617. Epub 2008 Jan 11. PMID: 18192543.
  4. Hoffman JR, Ratamess NA, Kang J, Rashti SL, Faigenbaum AD. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb 27;6:7. doi: 10.1186/1550-2783-6-7. PMID: 19250531; PMCID: PMC2651845.
  5. Yang MT, Lin HW, Chuang CY, Wang YC, Huang BH, Chan KH. Effects of 6-Week Betaine Supplementation on Muscular Performance in Male Collegiate Athletes. Biology (Basel). 2022 Jul 29;11(8):1140. doi: 10.3390/biology11081140. PMID: 36009767; PMCID: PMC9404903.
  6. Kusum K. Kharbanda, David D. Rogers, Mark E. Mailliard, Gerri L. Siford, Anthony J. Barak, Harriet C. Beckenhauer, Michael F. Sorrell, Dean J. Tuma, A Comparison of the Effects of Betaine and S-Adenosylmethionine on Ethanol-Induced Changes in Methionine Metabolism and Steatosis in Rat Hepatocytes1, The Journal of Nutrition, Volume 135, Issue 3, 2005, Pages 519-524, ISSN 0022-3166, https://doi.org/10.1093/jn/135.3.519.

Author: Pedro van Gaalen

When he’s not writing about sport or health and fitness, Pedro is probably out training for his next marathon or ultra-marathon. He’s worked as a fitness professional and as a marketing and comms expert. He now combines his passions in his role as managing editor at Fitness magazine.

When he's not writing about sport or health and fitness, Pedro is probably out training for his next marathon or ultra-marathon. He's worked as a fitness professional and as a marketing and comms expert. He now combines his passions in his role as managing editor at Fitness magazine.

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